Peer-reviewed publications

Submitted or Under review


  1. Lagarde B, Russell N, Esposito E, Desban L, Wyart C, Ogden D []. Simultaneous fluorescence imaging of tilted focal planes at two depths in thick neural tissue: Implementation with remote focus in a widefield electrophysiological microscope. biorxiv. DOI:10.1101/839050.
  2. Prendergast, AE, Jim, KK, Marnas, H, Desban, L, Quan, F, Djenoune, L, Roussel, J, Cantaut-Belarif, Y, Sahu, S, Bardet, PL, van de Beek, D, Vandenbroucke-Grauls, C#, Wyart, C# []. Central Sensory Neurons Detect and Combat Pathogens Invading the Cerebrospinal Fluid. CELL-D-19-01614. [Preparing resubmission to Cell]
  3. Orts-Del’Immagine, A, Cantaut-Belarif, Y,*, Thouvenin, O, Roussel, J, Baskaran, A, Langui, D, Koeth, F, Bivas, P, Lejeune, FX, Bardet, PL, Wyart C# []. Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo. Current Biology in press.
  4. Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Carbo-Tano, M, Verweij, F, Jurisch-Yaksi, N, Bardet, PL, Van Niel, G, Gallaire, F, Wyart C # []. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLife pii: e47699. DOI:10.7554/elife.47699.
  5. Desban, L, Prendergast, A, Roussel, J, Rosello, M, Geny, D, Wyart C#, Bardet, PL []. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology 17(4):e3000235. DOI:10.1371/journal.pbio.3000235.
  6. Bercier V, Hubbard JM, Fidelin K, Duroure K, Auer TO, Revenu C, Wyart C#, Del Bene F# []. Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Mol Neurodegener 10;14(1):27. DOI: 10.1186/s13024-019-0327-3.
  7. Severi, KE, Böhm, UL, Wyart C# []. Investigation of hindbrain activity during active locomotion reveals inhibitory neurons involved in sensorimotor processing, Scientific Reports 8:13615. DOI:10.1038/s41598-018-31968-4.
  8. Sternberg, JR, Prendergast, AE, Brosse, L, Cantaut-Belarif, Y, Thouvenin, O, Orts-Del'Immagine, A, Castillo, L, Djenoune, L, Kurisu, S, McDearmid, JR, Bardet, PL, Boccara, C, Okamoto, H, Delmas, P, Wyart C# []. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 9:3804. DOI:10.1038/s41467-018-06225-x.
  9. Cantaut-Belarif Y, Sternberg J, Thouvenin O, Wyart C#, Bardet PL# []. The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis. Current Biology 28:2479-2486.e4. DOI: 10.1016/j.cub.2018.05.079.
  10. Knafo S, Prendergast A, Thouvenin O, Nunes Figueiredo S, Wyart C# []. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. Bio Protoc 7(18):e2550. DOI:10.21769/BioProtoc.2550.
  11. Knafo S*, Fidelin K*, Prendergast A, Tseng PE, Parrin A, Dickey CW, Bohm UL, Nunes Figueiredo S, Thouvenin O, Pascal-Moussellard H, Wyart C # []. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. eLife 6:e25260. DOI: 10.7554/elife.25260.
  12. Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C # []. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports 7:719. DOI:10.1038/s41598-017-00350-1.
  13. Hubbard J, Böhm U, Prendergast A, Tseng PE, Stokes C, Newman M, Wyart C# []. Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Current Biology 26: 1-13. DOI:10.1016/j.cub.2016.08.026.
  14. Sternberg J*, Severi K*, Fidelin K, Gomez J, Ihara H, Alcheikh Y, Hubbard J, Kawakami K, Suster M, Wyart C # []. Optimization of Botulinum toxin to probe the role of specific interneurons in innate locomotion. Current Biology 26: 2319-28. DOI:10.1016/j.cub.2016.06.037.
  15. Hernandez O, Papagiakoumou E, Tanese D, Fidelin K, Wyart C, Emiliani V []. Three-dimensional spatiotemporal focusing of holographic patterns, Nature Communications 7:11928. DOI:10.1038/ncomms11928.
  16. Rupprecht P, Prendergast A, Wyart C, Friedrich RW []. Remote z-scanning with an acroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy. Biomedical Optics Express 7(5): 1656-1671. DOI:10.1364/BOE.7.00165.
  17. Böhm U*, Prendergast A*, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C# []. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications 7:10866. DOI:10.1038/ncomms10866.
  18. Fidelin K, Djenoune L, Stokes C, Prendergast A, Gomez J, Baradel A, Del Bene F, Wyart C# []. State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Current Biology 25: 3035-47. DOI:10.1016/j.cub.2015.09.070.
  19. Auer TO, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet JP, Wyart C, Suster M, Kawakami K, Wittbrodt J, Baier H, Del Bene F []. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLife 4:e05061. DOI:10.7554/elife.05061.
  20. De Vico Fallani F, Corazzol M, Sternberg J, Wyart C#, Chavez M []. Hierarchy of neural organization in the embryonic spinal cord: Granger-Causality graph analysis of in vivo calcium imaging data. IEEE Trans Neural Syst Rehabil Eng 23(3):333-41. DOI:10.1109/TNSRE.2014.2341632.
  21. Quan FB, Dubessy C, Galant S, Kenigfest NB, Djenoune L, Leprince J, Wyart C, Lihrmann I, Tostivint H []. Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PLoS One 10:e0119290. DOI:10.1371/journal.pone.0119290.
  22. Lauterbach MA, Ronzitti E, Sternberg JR, Wyart C, Emiliani V []. Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy. PLoS One 10: e0143681. DOI:10.1371/journal.pone.0143681.
  23. Goetz JG, Steed E, Ferreira RR, Roth S, Ramspacher C, Boselli F, Charvin G, Liebling M, Wyart C, Schwab Y, Vermot J []. Endothelial cilia mediate low flow sensing during zebrafish vascular development. Cell Reports 6:799-808. DOI: 10.1016/j.celrep.2014.01.032.
  24. Djenoune L, Khabou H, Joubert F, Nunes Figueiredo S, Bodineau L, Del Bene F, Burcklé C, Tostivint H, Wyart C# []. Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Frontiers in Neuroanatomy 6, 8:26. DOI:10.3389/fnana.2014.00026.
  25. Mirat O, Sternberg JR, Severi KE, Wyart C# []. ZebraZoom: an automated program for high-throughput behavioral analysis and categorization. Frontiers in Neural Circuits 7:107. DOI:10.3389/fncir.2013.00107.
  26. Hong E, Santhakumar K, Akitake CA, Ahn SJ, Thisse C, Thisse B, WYART C, Mangin JM, Halpern M []. Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. PNAS 110: 21171-76. DOI:10.1073/pnas.1319566110.
  27. Warp E, Agarwal G, Wyart C, Friedmann D, Oldfield CS, A Conner, Del Bene F, Arrenberg AB, Baier H, Isacoff EY []. Emergence of patterned activity in the developing zebrafish spinal cord. Current Biology 22: 93-102. DOI:10.1016/j.cub.2011.12.002.
  28. Del Bene F*, Wyart C*, Robles E, Tran A, Looger LL, Scott EK, Isacoff EY, Baier H []. Filtering of visual information in the tectum by an identified neural circuit. Science 330: 669-673. DOI:10.1126/science.1192949.
  29. Janovjak H, Szobota S, Wyart C, Trauner D, Isacoff EY []. A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nature Neuroscience 13: 1027-1032. DOI:10.1038/nn.2589.
  30. Wyart C*, Del Bene F*, Warp E, Scott EK, Trauner D, Baier H, Isacoff EY []. Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature 461: 407-410. DOI:10.1038/nature08323.
  31. Pautot S, Wyart C, Isacoff EY []. Colloid-guided assembly of oriented 3D neuronal networks. Nature Methods 5: 735-740. DOI:10.1038/nmeth.1236.
  32. Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY []. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron 45: 535-545. DOI:10.1016/j.neuron.2007.05.010.
  33. Wyart C, Webster WW, Chen JH, Wilson SR, McClary A, Khan RM, Sobel N []. Smelling a single component of male sweat alters levels of cortisol in women. The Journal of Neuroscience 27: 1261-1265. DOI:10.1523/JNEUROSCI.4430-06.2007.
  34. Salome R, Kremer Y, Dieudonne S, Léger JF, Krichevsky O, Wyart C, Chatenay D []. Ultrafast random-access scanning in two-photon microscopy using acousto-optic deflectors. Journal of Neuroscience Methods 154: 161-174. DOI:10.1016/j.jneumeth.2005.12.010.
  35. Wyart C#, Cocco S, Bourdieu L, Léger JF, Herr C, Chatenay D []. Dynamics of excitatory synaptic components in sustained firing at low rates. Journal of Neurophysiology 93: 3370-3380. DOI:10.1152/jn.00530.2004.
  36. Wyart C#, Ybert C, Bourdieu L, Herr C, Prinz C, Chatenay D []. Constrained synaptic connectivity in functional mammalian neuronal networks grown on patterned surfaces. Journal of Neuroscience Methods 117: 123-131. DOI:10.1016/s0165-0270(02)00077-8.
  37. Knowles RB, Wyart C, Buldyrev SV, Cruz L, Urbanc B, Hasselmo ME, Stanley HE, Hyman BT []. Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer’s disease. PNAS 96: 5274-5279. DOI:10.1073/pnas.96.9.5274.

Chapters and reviews

  1. Wyart C, Prendergast A []. Glia: A Gate Controlling Animal Behavior? Current Biology 29: R847-R850. doi: 10.1016/j.cub.2019.07.058.
  2. Miles G, Wyart C []. Motor control systems of the spinal cord and hindbrain. Curr Opin Physiol (COP) DOI:10.1016/j.cophys.2019.04.003.
  3. Wyart C, Thirumalai V []. Building behaviors, one layer at a time. eLife 8:e46375. DOI:10.7554/elife.46375.
  4. Wyart C []. Taking a big step towards understanding locomotion. Trends In NeuroScience (TINS) 41:869-870. DOI:10.1016/j.tins.2018.09.010.
  5. Knafo S, Wyart C []. Active mechanosensory feedback during locomotion in the zebrafish spinal cord. Curr Opin Neurobiol 52:48-53. DOI:10.1016/j.conb.2018.04.010.
  6. Orts-Del'Immagine A and Wyart C []. Quick Guide: Cerebrospinal fluid-contacting neurons. Current Biology 7(22):R1198-R1200. DOI:10.1016/j.cub.2017.09.017.
  7. Thouvenin O, Wyart C []. Tracking microscopy enables whole-brain imaging in freely moving zebrafish. Nat Methods 14(11):1041-1042. DOI:10.1038/nmeth.4474.
  8. Djenoune L, Wyart C []. Light on a sensory interface linking the cerebrospinal fluid to motor circuits in vertebrates. Journal of Neurogenetics 113-127. DOI:10.1080/01677063.2017.1359833.
  9. Wyart C []. Locomotion: Control from the Periphery? Current Biology Vol. 27, Issue 4, R152–R153. DOI:10.1016/j.cub.2017.01.001.
  10. Böhm, Wyart C []. Sensory circuits in motion. Curr Opin Neurobiol 41: 38-43. DOI:10.1016/j.conb.2016.07.007.
  11. Desban L, Wyart C []. A brain conditioned for social defeat. Science 352:42-3. DOI:10.1126/science.aaf6016.
  12. Prendergast A, Wyart C []. Locomotion: Electrical Coupling of Motor and Premotor Neurons. Current Biology 26: R235-7. DOI:10.1016/j.cub.2016.02.021.
  13. Sternberg JR, Wyart C []. Neuronal Wiring: Linking Dendrite Placement to Synapse Formation. Current Biology 25: 190-191. DOI:10.1016/j.cub.2015.01.006.
  14. Knafo S, Wyart C []. Optogenetic neuromodulation: new tools for monitoring and breaking neural circuits. Annals of Physical and Rehabilitation Medicine 58: 259-264. DOI:10.1016/
  15. Wyart C, Knafo S []. Sensorimotor Integration in the Spinal Cord, from Behaviors to Circuits: New Tools to Close the Loop? New Techniques in Systems Neuroscience. Springer p.197-234. DOI:10.1007/978-3-319-12913-6_8.
  16. Fidelin K, Wyart C []. Inhibition and motor control in the developing zebrafish spinal cord. Current Opinion in Neurobiology 26: 103-109. DOI:10.1016/j.conb.2013.12.016.
  17. Portugues R, Severi KE, Wyart C, Ahrens MB []. Optogenetics in a transparent animal: circuit function in the larval zebrafish. Current Opinion in Neurobiology 23: 119-126. DOI:10.1016/j.conb.2012.11.001.
  18. Del Bene F, Wyart C []. Optogenetics: a new enlightenment age for zebrafish neurobiology. Dev. Neurobiol 72:404-414. DOI:10.1002/dneu.20914.
  19. Wyart C, Del Bene F []. Let there be light: zebrafish neurobiology and the optogenetic revolution. Reviews in Neuroscience 22:121-130. DOI:10.1515/RNS.2011.013.
  20. Wyart C, Ybert C, Douarche C, Herr C, Chatenay D, Bourdieu L []. A new technique to control the architecture of neuronal networks in vitro. Karger Publishers vol 1, pp 23-57. DOI:10.1159/000083432.