Peer-reviewed publications

In the pipeline

  • Sridhar G, Wyart C, Costa AC#. Unraveling phenotypic variation in multiscale behavioral dynamics. bioRxiv. . submitted.
  • Carbo-Tano M, Fidelin K, Welch T, Narayan S, Ahrens M, Dubuc R, Wyart C#. Whole brain mapping of spinal-projecting neurons in larval zebrafish. bioRxiv (in revision at eLife). . under revision.
  • Verran E, Moizan L, Tocquer L, Quan FB#, Wyart C#. Diverse paths for chemoreception in ciliated neurons contacting the cerebrospinal fluid in the spinal cord. bioRxiv. . submitted.
  • Dhanasekar M, Fidelin K, Greco M, Lunsford ET, Carbo-Tano M, Deleuze C, Moisan L, Mora T, Walczak A, Wyart C#. Cerebrospinal Fluid Noradrenergic Signaling Sustains Motor Arrest by Suppressing Descending Motor Commands. bioRxiv (in revision at Nature Neuroscience). . under revision.
  • Jia X, Kumar A, Peysson N, Fidelin K, Didelot M, Lejeune C, Grosse-Wentrup M, Wyart C#. All-optical investigation reveals a hierarchical organization of vsx2+ reticulospinal neurons coordinating steering and forward locomotion. Research Square (in revision at Nature Communications). . under revision.
    • Guedes J, Voilley N, Lejeune FX, Ryan TJ, Wyart C#. Gender Equity in Life Sciences Funding: Impact of Positive Actions in Europe. Current Biology (invited essay) under revision.

      Published since 2018

      Articles

      • Messa G, Wyart C#. Serotonin signalling in the central nervous system is required for correct spine morphogenesis in zebrafish. Current Biology (in press). .
        • Romanato M, Costa AC, Jannou A, Zhou A, Cherif S, Hainque E, Maltête D, Derrey S, Yeche M, Karachi C, Wyart C, Lau B, Welter ML. Body-segment coordination as a new predictor of freezing of gait in people with Parkinson’s disease. Brain Communications, in press. Preprint: bioRxiv. .
        • Lunsford, ET#, Carbo-Tano, M, Wyart, C#. Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass. PNAS, 123:e2515782123. .
        • Wong AK, Cherng BW, Kakinuma H, Wyart, C, Okamoto H#. Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems. J Comp Neurol 533:e70105. .
        • Chen AB#, Duque M, Wang VM, Dhanasekar M, Mi X, Rymbek A, Tocquer L, Narayan S, Prober D, Yu G, Wyart, C, Engert F, Ahrens MB#. Norepinephrine changes behavioral state via astroglial purinergic signaling. Science 388,769-775(2025). .
        • Sridhar, G, Vergassola, M, Marques, J, Orger, M, Costa, A, Wyart, C#. Uncovering multiscale structure in the variability of larval zebrafish navigation. PNAS, 121:e2410254121. .
        • Costa AC#, Sridhar G, Wyart, C, Vergassola M. Fluctuating landscapes and heavy tails in animal behavior. PRX Life. 2024 2:10.1103/prxlife.2.023001. .
        • Carbo-Tano*, M, Lapoix*, M, Jia, X, Thouvenin, O, Pascucci, M, Auclair, F, Quan, FB, Albadri, S, Aguda, V, Farouj, Y, Hillman, EMC, Portugues, R, Del Bene, F, Thiele, TR, Dubuc R#, Wyart, C#. The mesencephalic locomotor region recruits distributed V2a reticulospinal neurons to drive forward locomotion. Nature Neuroscience 26:1775-1790. .
        • Xu H, Dugué GP, Cantaut-Belarif Y, Lejeune FX, Gupta S, Wyart, C#, Lehtinen, MK#. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Fluids Barriers CNS 20:89. .
        • Marie-Hardy L, Slimani L, Messa G, El Bourakkadi Z, Prigent A, Sayetta C, Koëth F, Pascal-Moussellard H, Wyart C#, Cantaut-Belarif Y#. Loss of CSF-contacting neuron sensory function is associated with a hyper-kyphosis of the spine reminiscent of Scheuermann's disease. Scientific Reports 13:5529. .
        • Bellegarda, C, Zavard, G, Moisan, L, Gray, RS, Wyart-Brochard, F, Joanny, JF, Cantaut-Belarif, Y, Wyart, C#. The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid. eLife 12: e86175. .
        • Prendergast AE, Jim KK, Marnas H, Desban L, Quan FB, Djenoune L, Laghi V, Hocquemiller A, Lunsford ET, Roussel J, Keiser L, Lejeune FX, Dhanasekar M, Bardet PL, Levraud JP, van de Beek D, Vandenbroucke-Grauls CMJE#, Wyart C#. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 33:940-956.e10. .
        • Chen, X, Ginoux, F, Mora, T, Walczak, A.M., Wyart, C#. Granger causality analysis for calcium transients in neuronal networks: challenges and improvements. eLife 12:e81279. .
        • Rajan G, Lafaye J, Faini G, Carbo-Tano M, Duroure K, Tanese D, Panier T, Candelier R, Henninger J, Britz R, Judkewitz B, Gebhardt C, Emiliani V, Debregeas G, Wyart C, Del Bene F. Evolutionary divergence of locomotion in two related vertebrate species. Cell Reports 38:110585. .
        • Orts-Del'Immagine A, Dhanasekar M, Lejeune FX, Roussel J, Wyart C#. A norepinephrine-dependent glial calcium wave travels in the spinal cord upon acoustovestibular stimuli. Glia 70(3):491-507. .
        • Reddy G#, Desban L, Tanaka H, Roussel J, Mirat O, Wyart C#. A lexical approach for identifying behavioural action sequences. PLoS Comput Biol. ;18(1):e1009672.
        • Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Gallaire, F, Wyart, C#. Automated Analysis of Cerebrospinal Fluid Flow and Motile Cilia Properties in The Central Canal of Zebrafish Embryos. Bio-protocol 11(5). .
          • Ming-Yue Wu, Martin Carbo-Tano, Olivier Mirat, Francois-Xavier Lejeune, Julian Roussel, Feng B Quan, Kevin Fidelin, Claire Wyart. Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed. Curr Biol. ;31(15):3315-3329.e5.
          • Shipley, FB, Dani, N, Xu H, Deister, C, Cui, J, Head, JP, Sadegh, C, Fame, RM, Shannon, ML, Flores, VI, Kishkovich, T, Jang, E, Klein, EM, Goldey, GJ, He, K, Zhang, Y, Holtzman, MJ, Kirchhausen, T, Wyart, C, Moore, CI, Andermann, ML#, Lehtinen, MK#. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron 108:623-639.e10. .
            • Oldfield, CS, Grossrubatscher, I, Chávez, M, Hoagland, A, Huth, AR, Carroll, EC, Prendergast, AE, Qu, T, Gallant, TL, Wyart, C#, Isacoff, EY#. Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture. eLife 9:e56619. .
            • Quan, FB, Desban, L, Mirat, O, Kermarquer, M, Roussel, J, Koëth, F, Marnas, H, Djenoune, L, Lejeune, FX, Tostivint, H, Wyart, C#. Somatostatin 1.1 contributes to the innate exploration of zebrafish larva. Scientific Reports 10: 15235. .
              • Cantaut-Belarif, Y, Penru, M, Orts Del’Immagine, A, Pézeron, G, Wyart, C#, Bardet, P-L#. Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development. eLife 9:e59469. .
              • Antinucci*, P, Dumitrescu*, AS, Deleuze, C, Morley, HJ, Leung, K, Hagley, T, Kubo, F, Baier, H, Bianco, IH#, Wyart, C#. A calibrated optogenetic toolbox of stable zebrafish opsin lines. eLife 9:e54937. .
              • Orts-Del’Immagine, A, Cantaut-Belarif, Y,*, Thouvenin, O, Roussel, J, Baskaran, A, Langui, D, Koeth, F, Bivas, P, Lejeune, FX, Bardet, PL, Wyart C#. Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo. Current Biology. . in press..
              • Desban, L, Prendergast, A, Roussel, J, Rosello, M, Geny, D, Wyart C#, Bardet, PL. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology. ;17(4):e3000235.
              • Bercier V, Hubbard JM, Fidelin K, Duroure K, Auer TO, Revenu C, Wyart C#, Del Bene F#. Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Mol Neurodegener. ;14(1):1–22.
              • Severi, KE, Böhm, UL, Wyart C#. Investigation of hindbrain activity during active locomotion reveals inhibitory neurons involved in sensorimotor processing. Scientific Reports. ;8:13615.
              • Sternberg, JR, Prendergast, AE, Brosse, L, Cantaut-Belarif, Y, Thouvenin, O, Orts-Del’Immagine, A, Castillo, L, Djenoune, L, Kurisu, S, McDearmid, JR, Bardet, PL, Boccara, C, Okamoto, H, Delmas, P, Wyart C#. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications. ;9:3804.
              • Cantaut-Belarif Y, Sternberg J, Thouvenin O, Wyart C#, Bardet PL#. The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis. Current Biology. ;28:2479-2486.e4.

              Chapters and reviews

              • Jia, X, Wyart, C#. Holographic Optogenetic Activation of Neurons Eliciting Locomotion in Head-Embedded Larval Zebrafish. Methods Molecular Biology 2707:125-140. .
              • Wyart, C#, Carbo-Tano M. Design of mechanosensory feedback during undulatory locomotion to enhance speed and stability. Curr Opin Neurobiol 83:102777. .
              • Wyart, C#, Carbo-Tano, M, Cantaut-Belarif, Y, Orts-Del’Immagine, A, Böhm, UL. Cerebrospinal fluid-contacting neurons: Roles in motion, posture, morphogenesis and host defense. Nature Reviews Neuroscience 24:540-556. .
              • Wyart, C#, Jim, KK, Prendergast, AE. Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections. Neuroscience 525:47-50. .
              • Wyart, C#. [Polymodal sensory integration at the interface with the cerebrospinal fluid]. Médecine Sciences, 39:537-543. .
              • Dallmann, CJ, Dickerson, BH, Simpson, JH, Wyart, C, Jayaram K#. Mechanosensory Control of Locomotion in Animals And Robots: Moving Forward. Integr Comp Biol 5:icad057. .
              • Wyart, C#. Unraveling the roles of cerebrospinal fluid-contacting neurons. eLife 12:e87054. .
              • Desban, L, Roussel, J, Michalski, N, Wyart, C#. Lateral line integrates mechanical and chemical cues to control exploration. bioRxiv. .
              • Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Carbo-Tano, M, Verweij, F, Jurisch-Yaksi, N, Bardet, PL, Van Niel, G, Gallaire, F, Wyart C #. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLife. ;pii:e47699.
              • Wyart C, Prendergast A. Glia: A Gate Controlling Animal Behavior?. Current Biology. ;29:R847-R850.
              • Miles G, Wyart C. Motor control systems of the spinal cord and hindbrain. Curr Opin Physiol (COP). .
              • Wyart C, Thirumalai V. Building behaviors, one layer at a time. eLife. ;8:e46375.
              • Wyart C. Taking a big step towards understanding locomotion. Trends In NeuroScience (TINS). ;41:869–870.
              • Knafo S, Wyart C. Active mechanosensory feedback during locomotion in the zebrafish spinal cord. Curr Opin Neurobiol. ;52:48–53.

              Published 2013 - 2018

              Articles

              • Knafo S, Prendergast A, Thouvenin O, Nunes Figueiredo S, Wyart C#. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. Bio Protoc. ;7(18):e2550.
              • Knafo S*, Fidelin K*, Prendergast A, Tseng PE, Parrin A, Dickey CW, Bohm UL, Nunes Figueiredo S, Thouvenin O, Pascal-Moussellard H, Wyart C #. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. eLife. ;6:e25260.
              • Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C #. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports. ;7:719.
              • Hubbard J, Böhm U, Prendergast A, Tseng PE, Stokes C, Newman M, Wyart C#. Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Current Biology. ;26:1–13.
              • Sternberg J*, Severi K*, Fidelin K, Gomez J, Ihara H, Alcheikh Y, Hubbard J, Kawakami K, Suster M, Wyart C #. Optimization of Botulinum toxin to probe the role of specific interneurons in innate locomotion. Current Biology. ;26:2319-28.
              • Hernandez O, Papagiakoumou E, Tanese D, Fidelin K, Wyart C, Emiliani V. Three-dimensional spatiotemporal focusing of holographic patterns,. Nature Communications. ;7:11928.
              • Rupprecht P, Prendergast A, Wyart C, Friedrich RW. Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy. Biomedical Optics Express. . 7(5): 1656-1671.
              • Böhm U*, Prendergast A*, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C#. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications. ;7:10866.
              • Fidelin K, Djenoune L, Stokes C, Prendergast A, Gomez J, Baradel A, Del Bene F, Wyart C#. State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Current Biology. ;25:3035-47.
              • Auer TO, Xiao T, Bercier V, Gebhardt C, Duroure K, Concordet JP, Wyart C, Suster M, Kawakami K, Wittbrodt J, Baier H, Del Bene F. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLife. ;4:e05061.
              • De Vico Fallani F, Corazzol M, Sternberg J, Wyart C#, Chavez M. Hierarchy of neural organization in the embryonic spinal cord: Granger-Causality graph analysis of in vivo calcium imaging data. IEEE Trans Neural Syst Rehabil Eng. ;23(3):333-41.
              • Quan FB, Dubessy C, Galant S, Kenigfest NB, Djenoune L, Leprince J, Wyart C, Lihrmann I, Tostivint H. Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PLoS One. ;10:e0119290.
              • Lauterbach MA, Ronzitti E, Sternberg JR, Wyart C, Emiliani V. Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy. PLoS One. ;10:e0143681.
              • Goetz JG, Steed E, Ferreira RR, Roth S, Ramspacher C, Boselli F, Charvin G, Liebling M, Wyart C, Schwab Y, Vermot J. Endothelial cilia mediate low flow sensing during zebrafish vascular development. Cell Reports. ;6:799–808.
              • Djenoune L, Khabou H, Joubert F, Nunes Figueiredo S, Bodineau L, Del Bene F, Burcklé C, Tostivint H, Wyart C#. Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Frontiers in Neuroanatomy. ;6, 8:26.
              • Mirat O, Sternberg JR, Severi KE, Wyart C#. ZebraZoom: an automated program for high-throughput behavioral analysis and categorization. Frontiers in Neural Circuits. ;7:107.
              • Hong E, Santhakumar K, Akitake CA, Ahn SJ, Thisse C, Thisse B, WYART C, Mangin JM, Halpern M. Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. PNAS. ;110:21171-76.

              Chapters and reviews

              Published before 2013

              Articles

              • Warp E, Agarwal G, Wyart C, Friedmann D, Oldfield CS, A Conner, Del Bene F, Arrenberg AB, Baier H, Isacoff EY. Emergence of patterned activity in the developing zebrafish spinal cord. Current Biology. ;22:93–102.
              • Del Bene F*, Wyart C*, Robles E, Tran A, Looger LL, Scott EK, Isacoff EY, Baier H. Filtering of visual information in the tectum by an identified neural circuit. Science. ;330:669–673.
              • Janovjak H, Szobota S, Wyart C, Trauner D, Isacoff EY. A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nature Neuroscience. ;13:1027–1032.
              • Wyart C*, Del Bene F*, Warp E, Scott EK, Trauner D, Baier H, Isacoff EY. Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature. ;461:407–410.
              • Pautot S, Wyart C, Isacoff EY. Colloid-guided assembly of oriented 3D neuronal networks. Nature Methods. ;5:735–740.
              • Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron. ;45:535–545.
              • Wyart C, Webster WW, Chen JH, Wilson SR, McClary A, Khan RM, Sobel N. Smelling a single component of male sweat alters levels of cortisol in women. The Journal of Neuroscience. ;27:1261–1265.
              • Salome R, Kremer Y, Dieudonne S, Léger JF, Krichevsky O, Wyart C, Chatenay D. Ultrafast random-access scanning in two-photon microscopy using acousto-optic deflectors. Journal of Neuroscience Methods. ;154:161–174.
              • Wyart C#, Cocco S, Bourdieu L, Léger JF, Herr C, Chatenay D. Dynamics of excitatory synaptic components in sustained firing at low rates. Journal of Neurophysiology. ;93:3370–3380.
              • Wyart C#, Ybert C, Bourdieu L, Herr C, Prinz C, Chatenay D. Constrained synaptic connectivity in functional mammalian neuronal networks grown on patterned surfaces. Journal of Neuroscience Methods. ;117:123–131.
              • Knowles RB, Wyart C, Buldyrev SV, Cruz L, Urbanc B, Hasselmo ME, Stanley HE, Hyman BT. Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer’s disease. PNAS. ;96:5274–5279.

              Chapters and reviews

              • Del Bene F, Wyart C. Optogenetics: a new enlightenment age for zebrafish neurobiology. Dev. Neurobiol. ;72:404–414.
              • Wyart C, Del Bene F. Let there be light: zebrafish neurobiology and the optogenetic revolution. Reviews in Neuroscience. ;22:121–130.
              • Wyart C, Ybert C, Douarche C, Herr C, Chatenay D, Bourdieu L. A new technique to control the architecture of neuronal networks in vitro. Karger Publishers. ;vol 1:23–57.